Buy a nice thermal paste if you plan overclocking. I have an AMD based rig and since I am not a hardcore gamer and I don't intend on overclocking, the pre-applied paste suits me fine. I assume that you're going to play rather high end games so, it would be best to buy a ceramic thermal paste, or another with better heat conductivity. They are expensive, but their heat transference level is way superior. Also, a liquid cooler isn't something that I'd pick. A good air cooler (I'd pick a Cooler Master MasterAir Maker 8, but any bigass noctua will do waaaaaaay fine) would be cheaper to maintain/buy and the temperature level wouldn't be much different. But hey, whatever floats your boat. To answer your question, it won't matter if 3 slots have 4 gb RAM and another has a 16 GB stick. It just looks somewhat unappealing in the definitions (28 gb ram? It just looks nasty imo). And, unless you're going to do video rendering and 3D modelation, 16 GB is enough to play every single game on high settings. Also, buy a GPU support. Those GPU's are heavy and put unnecessary stress on the motherboard.